演讲嘉宾

高绍荣


同济大学生命科学与技术学院院长 转化医学高等研究院副院长 教育部“长江学者”特聘教授、国家杰青获得者

研究方向

1、体细胞重编程的分子机制
2、利用疾病特异iPS细胞研究疾病发生机制
3、哺乳动物早期胚胎发育的分子机制


研究经历

1989-1993 山东农业大学动物科技学院学习并获学士学位。
1993-1996 中国农业大学动物科技学院学习并获硕士学位
1996-1999 中国科学院动物研究所生殖生物学国家重点实验室学习并获博士学位
1998-2000 美国布朗大学医学院,研究助理
2000-2002 英国罗斯林研究所基因表达与发育系做博士后研究
2002-2004 美国坦普尔大学菲尔斯癌症与分子生物学研究所做博士后研究
2004-2005 美国康涅狄格州大学再生生物学中心助理教授
2005-2011 北京生命科学研究所研究员
2011-2012 北京生命科学研究所高级研究员
2013- 同济大学生命科学与技术学院教授


主要学会兼职:

“干细胞研究”国家重大科学研究计划专家组成员
国家自然科学基金委第十四届专家评审组成员
国际干细胞学会(ISSCR)正式会员
国际生殖生物学会(SSR)正式会员
Cellular Reprogramming 编委
Cell Regeneration 编委
中国动物学会细胞及分子显微技术学会副理事长
中国干细胞学会理事
中国再生生物学会理事
中国干细胞工程技术学会理事


研究方向与主要学术成就:

主要利用体细胞核移植与诱导多能干细胞技术从事哺乳动物早期胚胎发育和体细胞重编程分子机制与干细胞研究。与中科院动物研究所周琪实验室在2009年分别独立报道了iPS小鼠的研究成果,从而在世界上首次证明了iPS细胞的真正多能性,被美国TIMES评为2009年世界十大医学突破之一。最近的研究证明DNA羟甲基化酶Tet1可以有效替代Oct4将体细胞重编程为iPS细胞并进一步阐释了其分子机制,而所形成的T-iPS细胞可以经四倍体补偿产生iPS小鼠并且没有肿瘤的发生。已经在包括Science, Nature Genetics, Cell Stem Cell, PNAS, Human Molecular Genetics, Stem Cells等国际知名学术期刊发表论文60余篇。


近期发表论文

  1. Gao R., Xiu W., Zhang L., Zang R., Yang L., Wang C., Wang M., Wang M., Yi L., Tang Y., Gao Y., Wang H., Xi J., Liu W., Wang Y., Wen X., Yu Y., Zhang Y., Chen L., Chen J., Gao S. Direct induction of neural progenitor cells transiently passes through a partially reprogrammed state. Biomaterials. 2016. 119. 53-67
  2. Wang Y., Gao S. Human Naive Embryonic Stem Cells: How Full Is the Glass? Cell Stem Cell. 2016. 18(3). 301-303
  3. Yang Y., Zhang X., Yi L., Hou Z., Chen J., Kou X., Zhao Y., Wang H., Sun X. F., Jiang C., Wang Y., Gao S. Naive Induced Pluripotent Stem Cells Generated From beta-Thalassemia Fibroblasts Allow Efficient Gene Correction With CRISPR/Cas9. Stem Cells Transl Med. 2016. 5(1). 8-19
  4. Liu X., Wang C., Liu W., Li J., Li C., Kou X., Chen J., Zhao Y., Gao H., Wang H., Zhang Y., Gao Y., Gao S. Distinct features of H3K4me3 and H3K27me3 chromatin domains in pre-implantation embryos. Nature. 2016. 537(7621). 558-562
  5. Xiong Z., Yi L., Cao D., He W., Chen J., Gao S., Sun X. Dravet syndrome with autism inherited from a paternal mosaic heterozygous mutation on SCN1A. J Neurol Sci. 2016. 369. 53-56
  6. Sun M., Liao B., Tao Y., Chen H., Xiao F., Gu J., Gao S., Jin Y. Calcineurin-NFAT Signaling Controls Somatic Cell Reprogramming in a Stage-Dependent Manner. J Cell Physiol. 2016. 231(5). 1151-1162
  7. Chen J., Chen X., Li M., Liu X., Gao Y., Kou X., Zhao Y., Zheng W., Zhang X., Huo Y., Chen C., Wu Y., Wang H., Jiang C., Gao S. Hierarchical Oct4 Binding in Concert with Primed Epigenetic Rearrangements during Somatic Cell Reprogramming. Cell Rep. 2016. 14(6). 1540-1554
  8. Liu W., Liu X., Wang C., Gao Y., Gao R., Kou X., Zhao Y., Li J., Wu Y., Xiu W., Wang S., Yin J., Liu W., Cai T., Wang H., Zhang Y., Gao S. Identification of key factors conquering developmental arrest of somatic cell cloned embryos by combining embryo biopsy and single-cell sequencing. Cell Discov. 2016. 2. 16010
  9. Kou Z., Wu Q., Kou X., Yin C., Wang H., Zuo Z., Zhuo Y., Chen A., Gao S., Wang X. CRISPR/Cas9-mediated genome engineering of the ferret. Cell Res. 2015. 25(12). 1372-1375
  10. Kang L., Gao S. Generation of Viable Mice from Induced Pluripotent Stem Cells (iPSCs) Through Tetraploid Complementation. Methods Mol Biol. 2015. 1330. 125-132
  11. Xu Q., Wang F., Xiang Y., Zhang X., Zhao Z. A., Gao Z., Liu W., Lu X., Liu Y., Yu X. J., Wang H., Huang J., Yi Z., Gao S., Li L. Maternal BCAS2 protects genomic integrity in mouse early embryonic development. Development. 2015. 142(22). 3943-3953
  12. Chen J., Gao Y., Huang H., Xu K., Chen X., Jiang Y., Li H., Gao S., Tao Y., Wang H., Zhang Y., Wang H., Cai T., Gao S. The combination of Tet1 with Oct4 generates high-quality mouse-induced pluripotent stem cells. Stem Cells. 2015. 33(3). 686-698
  13. Gao S., Zheng C., Chang G., Liu W., Kou X., Tan K., Tao L., Xu K., Wang H., Cai J., Tian J., Gao S. Unique features of mutations revealed by sequentially reprogrammed induced pluripotent stem cells. Nat Commun. 2015. 6. 6318
  14. Zhu X., Wang F., Zhao Y., Yang P., Chen J., Sun H., Liu L., Li W., Pan L., Guo Y., Kou Z., Zhang Y., Zhou C., He J., Zhang X., Li J., Han W., Li J., Liu G., Gao S., Yang Z. A gain-of-function mutation in Tnni2 impeded bone development through increasing Hif3a expression in DA2B mice. PLoS Genet. 2014. 10(10). e1004589
  15. 15. Tao Y., Zheng W., Jiang Y., Ding G., Hou X., Tang Y., Li Y., Gao S., Chang G., Zhang X., Liu W., Kou X., Wang H., Jiang C., Gao S. Nucleosome organizations in induced pluripotent stem cells reprogrammed from somatic cells belonging to three different germ layers. BMC Biol. 2014. 12. 109
  16. Liu W, Yin J, Kou X, Jiang Y, Gao H, Zhao Y, Huang B, He W, Wang H, Han Z, Gao S. (2014) Asymmetric reprogramming capacity of parental pronuclei in mouse zygotes. Cell Reports (in press)
  17. Le R, Kou Z, Jiang Y, Li M, Huang B, Liu W, Li H, Kou X, He W, Rudolph KL, Ju Z, Gao S. (2014) Enhanced telomere rejuvenation in pluripotent cells reprogrammed via nuclear transfer relative to induced pluripotent stem cells. Cell Stem Cell 14(1):27-39. 
  18. Gao Y, Chen J, Li K, Wu T, Huang B, Liu W, Kou X, Zhan Y, Huang H, Jiang Y, Yao C, Liu X, Lu Z, Xu Z, Kang L, Chen J, Wang H, Cai T, Gao S. (2013) Replacement of Oct4 by Tet1 during iPSC induction reveals an important role of DNA methylation and hydroxymethylation in reprogramming. Cell Stem Cell 12(4):453-69. (Cover Story; Previewed by Cell Stem Cell)
  19. Yuan W, Wu T, Fu H, Dai C, Wu H, Liu N, Li X, Xu M, Zhang Z, Niu T, Han Z, Chai J, Zhou XJ, Gao S, Zhu B. (2012) Dense chromatin activates Polycomb repressive complex 2 to regulate H3 lysine 27 methylation.Science 337(6097):971-5. (Co-correspondence)
  20. Kang L, Wang J, Zhang Y, Kou Z, Gao S. (2009) iPS cells can support full term development of tetraploid blastocyst-complemented embryos. Cell Stem Cell 5(2):135-138. (Highlighted by Nature, Nature China; Selected as “Must Read” by Faculty 1000; Featured in TIME Magazine, Washington Post, Wall Street Journal, Xinhua News, USA Today, The Scientist, The Economist, ABC News, The Independent, Scientific America etc.)
  21. Wang S, Kou Z, Jing Z, Zhang Y, Guo X, Dong M., Wilmut I, Gao S. (2010) Proteome of mouse oocytes at different developmental stages. Proc. Natl. Acad. Sci. USA 107(41):17639-44.
  22. Liu Y, Cheng H, Gao S, Lu X, He F, Hu L, Hou D, Zou Z, Li Y, Zhang H, Xu J, Kang L, Wang Q, Yuan W, Gao S, Cheng T. (2013) Reprogramming of MLL-AF9 leukemia cells into pluripotent stem cells. Leukemia. 2013 Oct 22. doi: 10.1038/leu.2013.304. [Epub ahead of print] (Co-correspondence)
  23. Jiao J, Yang Y, Shi Y, Chen J, Gao R, Fan Y, Yao H, Liao W, Sun XF, Gao S. (2013) Modeling Dravet syndrome using induced pluripotent stem cells (iPSCs) and directly converted neurons. Hum Mol Genet. 22(21):4241-52.
  24. Jiao J, Dang Y, Yang Y, Gao R, Zhang Y, Kou Z, Sun XF, Gao S. (2013) Promoting reprogramming by FGF2 reveals that the extracellular matrix is a barrier for reprogramming fibroblasts to pluripotency. Stem Cells 31(4):729-40.
  25. Wang Y, Zheng C, Jiang Y, Zhang J, Chen J, Yao C, Zhao Q, Liu S, Chen K, Du J, Yang Z, Gao S. (2012) Genetic correction of β-thalassemia patient-specific iPS cells and its use in improving hemoglobin production in irradiated SCID mice. Cell Research 22(4):637-48.
  26. Yang P, Wang Y, Chen J, Li H, Kang L, Zhang Y, Chen S, Zhu B, Gao S. (2011) RCOR2 is a subunit of the LSD1 complex that regulates ES cell property and substitutes for SOX2 in reprogramming somatic cells into pluripotency. Stem Cells 29(5):791-801.
  27. Wu T, Wang H, He J, Kang L, Jiang Y, Liu J, Zhang Y, Kou Z, Liu L, Zhang X, Gao S. (2011) Reprogramming of trophoblast stem cells into pluripotent stem cells by Oct4. Stem Cells 29(5):755-63.
  28. Kang L, Wu T, Tao Y, Yuan Y, He J, Zhang Y, Luo T, Kou Z, Gao S. (2011) Viable mice produced from 3-factor induced pluripotent stem (iPS) cells through tetraploid complementation. Cell Research 21(3):546-9.
  29. Hu J, Wang F, Yuan Y, Zhu X, Wang Y, Zhang Y, Kou Z, Wang S, Gao S. (2010) The novel importin-alpha family member Kpna7, is required for normal fertility and fecundity in the mouse. J. Biol. Chem. 285(43):33113-22.
  30. Kou Z, Kang L, Yuan Y, Tao Y, Zhang Y, Wu T, He J, Wang J, Liu Z, Gao S. (2010) Mice cloned from induced pluripotent stem cells (iPSCs). Biol. Reprod. 83:238-243.
  31. Zhao Q, Wang J, Zhang Y, Kou Z, Liu S and Gao S. (2010) Generation of histocompatible androgenetic embryonic stem cells using spermatogenic cells. Stem Cells 2010; 28(2):229-239.
  32. Zhang M, Wang F, Kou Z, Zhang Y, Gao S. (2009) Defective chromatin structure in somatic cell cloned embryos. J. Biol. Chem. 284(37):24981-7.
  33. Guo X, Gao S. (2009) LGN regulates meiotic spindle organization, anchoring and involves in cortical polarization during mouse oocytes maturation. Cell Research 19(7):838-48.
  34. Wang Y, Jiang Y, Liu S, Sun X, Gao S. (2009) Generation of induced pluripotent stem cells from human beta-thalassemia fibroblast cells. Cell Research 19(9):1120-3.
  35. Sung LY*, Gao S*, Shen H, Yu H, Song Y, Smith SL, Chang CC, Kuo L, Lian J, Tian XC, Tuck DP, Weissman SM, Yang X, Cheng T (2006) Differentiated cells are more efficient than adult stem cells for cloning by somatic cell nuclear transfer. Nat. Genet. 38(11): 1323-1328. (* Co-first author)