演讲嘉宾

刘 东


南通大学神经再生重点实验室 教授、硕士生导师

2011年获德国马克斯-德尔布吕克分子医学中心(Max-DelbrückCenterforMolecularMedicine)/柏林自由大学(FreeUniversityofBerlin),自然科学博士学位(magnacumlaude)。
从2012年8月起任南通大学神经再生重点实验室副教授,2013年起担任硕士研究生导师。中国解剖学会再生医学专业委员会委员,江苏省发育与细胞学会理事。主讲本科生《分子生物学》和研究生《高级分子生物学》课程。

研究方向

1、鉴定参与血管新生以及神经系统发育过程中的全新的调控分子。
2、组织再生过程中血管化的过程及调控机制。
3、利用多种遗传操作技术建立转基因和基因敲除斑马鱼模型。
4、筛选调控血管内皮细胞和运动神经元行为的天然化合物。


近期发表论文

  1. WangX, Ling CC, Li L, Qin Y, Qi J, Liu X, You B, Shi Y, Zhang J, Jiang Q, Xu H, SunC, You Y, Chai R, Liu D. Microrna-10a/10b represses a novel target gene mib1 toregulate angiogenesis. Cardiovascular research. 2016;110:140-150(通讯作者)
  2. WangX, Wang X, Yuan W, Chai R, Liu D. Egfl6 is involved in zebrafish notochorddevelopment. Fish physiology and biochemistry. 2015;41:961-969(通讯作者)
  3. WangX, Chong M, Wang X, Wang H, Zhang J, Xu H, Zhang J, Liu D. Block the functionof nonmuscle myosin ii by blebbistatin induces zebrafish embryo cardia bifida.In vitro cellular & developmental biology. Animal. 2015;51:211-217(通讯作者)
  4. XuM, Liu D, Dong Z, Wang X, Liu Y, Baas PW, Liu M. Kinesin-12 influences axonalgrowth during zebrafish neural development. Cytoskeleton (Hoboken).2014;71:555-563(通讯作者)
  5. WangX, Li L, Liu D. Expression analysis of integrin beta1 isoforms during zebrafishembryonic development. Gene Expr Patterns. 2014;16:86-92(通讯作者)
  6. HuangY, Wang X, Xu M, Liu M, Liu D. Nonmuscle myosin ii-b (myh10) expressionanalysis during zebrafish embryonic development. Gene Expr Patterns.2013;13:265-270(通讯作者)
  7. LiuD, Krueger J, Le Noble F. The role of blood flow and micrornas in blood vesseldevelopment. Int J Dev Biol. 2011;55:419-429(第一作者)
  8. JiangQ, Liu D, Sun S, Hu J, Tan L, Wang Y, Gui Y, Yu M, Song H. Critical role ofconnexin43 in zebrafish late primitive and definitive hematopoiesis. Fishphysiology and biochemistry. 2009;36:945-951(第一作者)
  9. JiangQ, Liu D, Gong Y, Wang Y, Sun S, Gui Y, Song H. Yap is required for thedevelopment of brain, eyes, and neural crest in zebrafish. Biochem Biophys ResCommun. 2009;384:114-119(第一作者)
  10. LiuD, Wang YX, Hu JY, Sun SN, Song HY. The effects of connexin43 down regulationon the development of the embryonic heart and vasculature in zebrafish.Progress in Biochemistry and Biophysics. 2008;35:766-771(第一作者)
  11. WangYX, Qian LX, Liu D, Yao LL, Jiang Q, Yu Z, Gui YH, Zhong TP, Song HY. Bonemorphogenetic protein-2 acts upstream of myocyte-specific enhancer factor 2a tocontrol embryonic cardiac contractility. Cardiovascular research.2007;74:290-303
  12. SunSN, Gui YH, Wang YX, Qian LX, Jiang Q, Liu D, Song HY. Effect of dihydrofolatereductase gene knock-down on the expression of heart and neural crestderivatives expressed transcript 2 in zebrafish cardiac development. Chin Med J(Engl). 2007;120:1166-1171
  13. KruegerJ, Liu D, Scholz K, Zimmer A, Shi Y, Klein C, Siekmann A, Schulte-Merker S,Cudmore M, Ahmed A, le Noble F. Flt1 acts as a negative regulator of tip cellformation and branching morphogenesis in the zebrafish embryo. Development.2011;138:2111-2120
  14. KleinC, Mikutta J, Krueger J, Scholz K, Brinkmann J, Liu D, Veerkamp J, Siegel D,Abdelilah-Seyfried S, le Noble F. Neuron navigator 3a regulates liverorganogenesis during zebrafish embryogenesis. Development. 2011;138:1935-1945
  15. SangQ, Zhang J, Feng R, Wang X, Li Q, Zhao X, Xing Q, Chen W, Du J, Sun S, Chai R,Liu D, Jin L, He L, Li H, Wang L. Ildr1b is essential for semicircular canaldevelopment, migration of the posterior lateral line primordium and hearingability in zebrafish: Implications for a role in the recessive hearing impairmentdfnb42. Hum Mol Genet. 2014;23:6201-6211
  16. LiS, Liu Q, Wang Y, Gu Y, Liu D, Wang C, Ding G, Chen J, Liu J, Gu X.Differential gene expression profiling and biological process analysis inproximal nerve segments after sciatic nerve transection. PLoS One.2013;8:e57000
  17. JiangQ, Lagos-Quintana M, Liu D, Shi Y, Helker C, Herzog W, le Noble F. Mir-30aregulates endothelial tip cell formation and arteriolar branching.Hypertension. 2013;62:592-598