基因编辑学术研讨会 -2017年3月 上海
演讲嘉宾

王晗


苏州大学 教授

王晗,博士,博士生导师,苏州大学生物钟研究中心主任。获美国韦恩州立大学博士学位;曾在美国佐治亚医学院和俄勒冈大学从事博士后研究;曾任美国俄克拉荷马大学助理教授(Assistant Professor)。目前任苏州大学特聘教授、江苏特聘教授、江苏省生物钟研究创新团队领军人才、国家重大科学研究计划生物钟研究项目首席科学家、国际时间生物学会(International Society of Chronobiology)理事、《Chronobiology International》杂志编委、中国中西医结合学会时间生物医学专业委员会主任,中国睡眠研究会理事, 中国睡眠研究会睡眠节律专业委员会副主任和中国斑马鱼研究会常务理事。

王晗

研究方向

主要研究方向为斑马鱼生物钟和睡眠分子遗传和基因组调控机制、生物钟对生殖和发育的影响、生物钟调节演化机制等。发现了生物钟调控注意力缺陷多动症(ADHD) 的新机制、Period2 在生物钟调节环路中的双重作用机制以及Rev-erbα对自噬的直接调节机制;阐明了斑马鱼生物钟基因clock、bmal、per 和cry 等的分子演化机制;建立了斑马鱼生物钟基因全套突变体库。已在在Nature Genetics、Autophagy、 Journal of Neuroscience、Journal of Biological Chemistry、Development、Journal of Pineal Research 等杂志发表60 余篇学术论文。

生物360精选了王晗教授在2015-2016年发表的3篇文章,翻译摘要以供读者更好的了解其工作成果,详情访问

研究经历

1980-1984,安徽大学,学士。
1984-1987,中国科学院,硕士。
1991-1996,美国密执安州韦恩州立大学,博士。
1996-1998,美国佐治亚医学院分子医学遗传研究所斑马鱼分子遗传学实验室,博士后。
1998-2003,美国俄勒冈大学神经科学研究所斑马鱼遗传学实验室,博士后。
2003-2009,美国俄克拉荷马大学助理教授,斑马鱼遗传学和基因组学实验室主任。
2009-至今,苏州大学医学部基础医学与生物科学学院特聘教授。
2011-至今,苏州大学生物钟研究中心主任。
2011-至今,江苏省特聘教授。
2012-至今,国家重大科学研究计划(973)项目首席科学家。


近期发表论文

  1. Braasch Ingo, Gehrke Andrew R., Smith Jeramiah J., Kawasaki Kazuhiko, Manousaki Tereza, Pasquier Jeremy, Amores Angel, Desvignes Thomas, Batzel Peter, Catchen Julian, Berlin Aaron M., Campbell Michael S., Barrell Daniel, Martin Kyle J., Mulley John F., Ravi Vydianathan, Lee Alison P., Nakamura Tetsuya, Chalopin Domitille, Fan Shaohua, Wcisel Dustin, Cañestro Cristian, Sydes Jason, Beaudry Felix E. G., Sun Yi, Hertel Jana, Beam Michael J., Fasold Mario, Ishiyama Mikio, Johnson Jeremy, Kehr Steffi, Lara Marcia, Letaw John H., Litman Gary W., Litman Ronda T., Mikami Masato, Ota Tatsuya, Saha Nil Ratan, Williams Louise, Stadler Peter F., Wang Han, Taylor John S., Fontenot Quenton, Ferrara Allyse, Searle Stephen M. J., Aken Bronwen, Yandell Mark, Schneider Igor, Yoder Jeffrey A., Volff Jean-Nicolas, Meyer Axel, Amemiya Chris T., Venkatesh Byrappa, Holland Peter W. H., Guiguen Yann, Bobe Julien, Shubin Neil H., Di Palma Federica, Alföldi Jessica, Lindblad-Toh Kerstin, Postlethwait John H. The spotted gar genome illuminates vertebrate evolution and facilitates human-to-teleost comparisons. Nature genetics. 2016. 48(4). 427-437
  2. Wang M, Zhong Z, Zhong Y, Zhang W, Wang H. The Zebrafish Period2 Protein Positively Regulates the Circadian Clock through Mediation of Retinoic Acid Receptor (RAR)-related Orphan Receptor α (Rorα). The Journal of Biological Chemistry. 2015;290(7):4367-4382. doi:10.1074/jbc.M114.605022.
  3. Zhong, Z., Niu, P., Wang, M., Huang, G., Xu, S., Sun, Y.,... Wang, H. (2016). Targeted disruption of sp7 and myostatin with CRISPR-Cas9 results in severe bone defects and more muscular cells in common carp. [Journal Article; Research Support, Non-U.S. Gov't]. Sci Rep, 6, 22953. doi: 10.1038/srep22953
  4. Bo, L., Liu, Z., Zhong, Y., Huang, J., Chen, B., Wang, H.,... Xu, Y. (2016). Iron deficiency anemia's effect on bone formation in zebrafish mutant. [Journal Article]. Biochem Biophys Res Commun, 475(3), 271-276. doi: 10.1016/j.bbrc.2016.05.069
  5. Huang, G., Zhang, F., Ye, Q., & Wang, H. (2016). The circadian clock regulates autophagy directly through the nuclear hormone receptor Nr1d1/Rev-erbalpha and indirectly via Cebpb/(C/ebpbeta) in zebrafish. [Journal Article]. Autophagy, 12(8), 1292-1309. doi: 10.1080/15548627.2016.1183843
  6. Huang, J., Zhong, Z., Wang, M., Chen, X., Tan, Y., Zhang, S.,... Wang, H. (2015). Circadian modulation of dopamine levels and dopaminergic neuron development contributes to attention deficiency and hyperactive behavior. [Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't]. J Neurosci, 35(6), 2572-2587. doi: 10.1523/JNEUROSCI.2551-14.2015
  7. Liu, C., Hu, J., Qu, C., Wang, L., Huang, G., Niu, P.,... Wang, H. (2015). Molecular evolution and functional divergence of zebrafish (Danio rerio) cryptochrome genes. [Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't]. Sci Rep, 5, 8113. doi: 10.1038/srep08113
  8. Wang, F., Huang, G. D., Tian, H., Zhong, Y. B., Shi, H. J., Li, Z.,... Sun, F. (2015). Point mutations in KAL1 and the mitochondrial gene MT-tRNA(cys) synergize to produce Kallmann syndrome phenotype. [Journal Article; Research Support, Non-U.S. Gov't]. Sci Rep, 5, 13050. doi: 10.1038/srep13050
  9. Zhang, S., Xu, M., Huang, J., Tang, L., Zhang, Y., Wu, J.,... Wang, H. (2014). Heme acts through the Bach1b/Nrf2a-MafK pathway to regulate exocrine peptidase precursor genes in porphyric zebrafish. [Journal Article; Research Support, N.I.H., Extramural]. Dis Model Mech, 7(7), 837-845. doi: 10.1242/dmm.014951
  10. J. Sun, F. Q. Fu, W.C. Gu, R.H. Yan, G. B.Zhang, Z. Y. Shen, Y.H.Zhou, H. Wang, B.R. Shen, X.G.Zhang. Origination of new immunological functions in the costimulatory molecule B7-H3: The role of exon duplication in evolution of the immune Ssystem. PLOS ONE e24751   DOI: 10.1371/journal.pone.0024751, 2011。
  11. R. P. Hu, X. L. Gong, Y. M.  Duan, N. Li, Y. Che, Y. L. Cui, M. Zhou, C. Liu, H. Wang and F. S. Hong.  Neurotoxicological effects and the impairment of spatial recognition memory in mice caused by exposure to TiO2 nanoparticles. Biomaterials 31:8043-8050,2010.
  12. Y. M. Duan, J. Liu, L.L Ma, N. Li, H.T. Liu, J. Wang, L. Zheng, C. Liu, X. F. Wang, X. Y. Zhao, J. Y. Yan, S. S. Wang, H. Wang, X. Y. Zhang and F.S. Hong. Toxicological characteristics of nanoparticulate anatase titanium dioxide in mice. Biomaterials 31:894-899,2010.
  13. L.L. Ma, J. Liu, N. Li, J.Wang, Y .M. Duan, J.Y Yan., H. T. Liu, H. Wang and F.S. Hong. Oxidative stress in the brain of mice caused by translocated nanoparticulate TiO2 delivered to the abdominal cavity. Biomaterials 31:99-105,2010.
  14. L. L. Ma,  J .F.  Zhao,  J. Wang , J. Liu, Y. M. Duan,  H.T. Liu, N. Li, J. Y. Yan, J. Ruan, H. Wang and F.S. Hong. The acute liver injury in mice caused by nano-anatase TiO2. Nanoscale Research Letters 4:1275–1285, 2009.
  15. H. Wang*.Comparative genomic analysis of teleost fish bmal genes. Genetica 136:149-161,2009.
  16. H. Wang*. Comparative analysis of period genes in teleost fish genomes. Journal of Molecular Evolution 67:29-40,2008。
  17. H. Wang*. Comparative analysis of teleost fish genomes reveals preservation of different ancient clock duplicates in different fishes. Marine Genomics 1:69-78,2008.
  18. H. Wang*, J. Kesinger, Q. Zhou, J. D. Wren, G. Martin, S. Turner. Y. Tang, B. Frank, and M. Centola. Identification and expression of zebrafish ocular formation genes. Genome 51:222-235,2008.
  19. H. Wang*, Q. Zhou, J. Kesinger, C. Norris and Cammi Valdez. Heme regulates exocrine peptidase precursor genes in zebrafish. Experimental Biology and Medicine 232:1170-1180, 2007.
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  21. H. Wang, E. M. Lee, S. Sperber, S. Lin, M. Ekker and Q. Long. Isolation and expression of zebrafish zinc-finger transcription factor gene tsh1. Gene Expression Patterns 7:318-322, 2007.
  22. A. E. Tucker, I. I. Salles, D. E. Voth, W. Ortiz-Leduc, H. Wang, I. Dozmorov, M. Centola and J. D. Ballard. Decreased glycogen synthase kinase 3-beta levels and related physiological changes in Bacillus anthracis lethal toxin-treated macrophages. Cellular Microbiology 5:523-532. (ISI times cited: 25) ,2003.
  23. R. M. Young, S. Marty, Y. Nakano, H. Wang, D. Yamamoto, S. Lin, and M. L. Allende. Zebrafish yolk-specific not really started (nrs) gene is a vertebrate homolog of the Drosophila spinster gene and is essential for embryogenesis. Developmental Dynamics 223:298-305. 2002.