演讲嘉宾

谢安勇


浙江大学转化医学研究院及浙江大学医学院附属邵逸夫医院,研究员、博士生导师

研究方向

1、肿瘤基因组不稳定性及肿瘤靶向药物研发
2、CRISPR基因编辑技术改良与应用
3、肝癌发生机制及临床应用研究


研究经历

1988-1992年 北京大学 植物生理学 学士
1992-1995年 中国科学院植物研究所 分子生物学 硕士
1995-2002年 中国科学院植物研究所 植物分子生物学 助理研究员
1996-2002年 美国 University of Missouri at Columbia 生物化学 博士
1999-2001年 美国 University of Missouri at Columbia 工商管理 硕士
2002-2008年 美国 哈佛医学院/贝斯以色列女执事医疗中心 博士后
2008-2014年 美国 哈佛医学院 讲师
2014—今 浙江大学转化医学研究院及附属邵逸夫医院 教授   


近期发表论文

  1. Liu J, Li J, Fu W, Tang J, Feng X, Chen J, Liang Y, Jin R, Xie A, Cai X.Adenoviral delivery of truncated MMP-8 fused with the hepatocyte growth factor mutant 1K1 ameliorates liver cirrhosis and promotes hepatocyte proliferation. Drug Des Devel Ther,2015;9:5655-67.
  2. Liu X-S, Chandramouly G, Rass E, Guan Y, Wang G, Hobbs RM, Rajendran A, Xie A, Shah JV, Davis AJ, Scully R, Lunardi A, Pandolfi PP. LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair.Nat Commun, 2015; 6:8325.
  3. Liu P, Gan W, Guo C, Xie A, Gao D, Guo J, Zhang J, Willis N, Su A, Asara JM, Scully R, Wei W. Akt-mediated phosphorylation of XLF impairs non-homologous end joining DNA repair. Mol Cell, 2015;57: 648–661.
  4. Hu Y, Petit SA, Ficarro SB, Toomire KJ, Xie A, Lim E, Cao SA, Park E, Eck MJ, Scully R, Brown M, Marto JA, Livingston DM. PARP1-driven poly-ADP-ribosylation regulates BRCA1 function in homologous recombination-mediated DNA repair.Cancer Discov, 2014; 4:1430-1447.
  5. Chandramouly G, Kwok A, Huang B, Willis NA, Xie A, Scully R. BRCA1 and CtIP suppress long tract gene conversion between sister chromatids. Nat Commun, 2013,4:2404.
  6. Rass E, Chandramouly G, Zha S, Alt FW, Xie A*. Ataxia telangiectasia mutated (ATM) is dispensable for endonuclease I-SceI-induced homologous recombination in mouse embryonic stem cells. J Biol Chem, 2013,288:7086-7095. (*, Corresponding author)
  7. Hartlerode AJ, Guan Y, Rajendran A, Ura K, Schotta G, Xie A, Shah JV, Scully R. Impact of histone H4 lysine 20 methylation on 53BP1 responses to chromosomal double strand breaks. PLoS One, 2012,7:e49211.
  8. Nguyen CL, Possemato R, Bauerlein EL, Xie A, Scully R, Hahn WC. Nek4 regulates entry into replicative senescence and the response to DNA-damage in human fibroblasts. Mol Cell Biol, 2012,32: 3963-3977.
  9. Hu Y, Scully R, Sobhian B, Xie A, Shestokova E, Livingston DM. RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear foci. Genes Dev 2011; 25:685-700.
  10.  Xie A, Odate S, Chandramouly G, Scully R. H2AX post-translational modifications in the ionizing radiation response and homologous recombination. Cell Cycle 2010; 9: 3602-3610. (Highlighted in News and Views in Cell Cycle, 2010; 9:3845).
  11.  Xie A*, Kwok A, Scully R. Role of mammalian Mre11 in classical and alternative nonhomologous end joining. Nat Struct Mol Biol 2009; 16:814-818 (*, Co-corresponding authorship). (Highlighted in News and Views in Nat Struct Mol Biol 2009; 16:798-800).
  12.  Xie A, Hartlerode A, Stucki M, Odate S, Puget N, Kwok A, Nagaraju G, Yan C, Alt FW, Chen J, Jackson SP, Scully R. Distinct roles of chromatin-associated factors MDC1 and 53BP1 in mammalian double strand break repair. Mol Cell 2007; 28:1045-1057. (Evaluated and recommended by Faculty of 1000).
  13. Nagaraju G, Odate S, Xie A, Scully R. Differential regulation of short- and long-tract gene conversion between sister chromatids by Rad51C.Mol Cell Biol 2006; 26:8075-8086.
  14.  Xie A, Puget N, Shim I, Odate S, Jarzyna I, Bassing CH, Alt FW, Scully R. Control of sister chromatid recombination by histone H2AX. Mol Cell 2004; 16:1017-1025.
  15.  Xie A-Y and Folk WR. Inhibition of polyomavirus ori-dependent DNA replication by mSin3B.J Virol 2002; 76:11809-11818.
  16.  Xie A-Y, Bermudez VP, Folk WR. Stimulation of DNA replication from the polyomavirus origin by PCAF and GCN5 acetyltransferases: Acetylation of large T antigen.Mol Cell Biol 2002; 22:7907-7918.
  17. Berjanskii MV, Riley MI, Xie A, Semenchenko V, Folk WR, Van Doren, SR. NMR structure of the N-terminal J domain of murine polyomavirus T antigens. Implications for DnaJ-like domains and for mutations of T antigens. J Biol Chem 2000; 275:36094-36103.
  18. Yong W-D, Liang T-B, Xie A-Y, Li C, Song Y-R. PhbB, phbC gene expression in E. coli and their transformation and identification in potato.Acta Botanica Sinica 1998; 40:615-621.
  19.  Xie A-Y, Cui X-J, Song Y-R. Cloning and sequencing of Alcaligenes eutrophus H16 phbB and phbC genes and construction of their plant expression vectors.Acta Botanica Sinica 1995; 37:581-588.