演讲嘉宾

朱健康


中国科学院上海生命科学研究院 美国科学院院士

研究方向

1、渗透胁迫的感应和信号传导
2、低温胁迫的感应和信号传导
3、耐盐和耐氧化的机制
4、RNA介导的DNA甲基化
5、DNA去甲基化及其调控

 
   

研究经历

1983-1987, 中国, 北京农业大学 土壤农业化学 获学士学位
1987-1990, 美国, 加州大学河滨分校 植物学 获硕士学位
1990-1993, 美国, 普度大学 植物生理学 获博士学位
1994.6 美国, 洛克菲勒大学 分子生物学 博士后
1995-1996, 美国, 奥本大学植物与微生物学系 助理教授
1996-1998, 美国, 亚利桑那大学植物科学系 助理教授
1999-2000, 美国, 亚利桑那大学植物科学系 副教授
2000-2003, 美国, 亚利桑那大学植物科学系 教授
2004-2006, 美国, 加州大学河滨分校植物学与植物科学系 特聘教授, 研究所所长
2007-2010, 美国, 加州大学河滨分校植物学与植物科学系 Jane Johnson讲座教授
2009.07-2011.06, 沙特, KAUST大学植物逆境基因组中心 主任
2010-至今, 美国, 普度大学生物化学与园艺及园林系 杰出教授
2011.7-至今,中科院上海生命科学研究院 研究员 顶尖千人计划


获奖经历

2011年 入选中央“顶尖千人计划”
2010年 入选美国科学院院士
2008年 被Thomson Reuters 评为1997-2007年度美国引用率最高的植物学科学家
2005年 获普渡大学农学杰出校友奖
2004年 美国科学促进会会员
2003年 美国植物生物学家学会Charles Albert Shull奖
2002年 亚利桑那大学农业和生命科学学院年度科学家


近期发表论文

  1. 1. Yan, J., Zhao, C., Zhou, J., Yang, Y., Wang, P., Zhu, X., … Zhu, J.-K. (2016). The miR165/166 Mediated Regulatory Module Plays Critical Roles in ABA Homeostasis and Response in Arabidopsis thaliana. PLoS Genetics, 12(11), e1006416. http://doi.org/10.1371/journal.pgen.1006416
  2. Tang, K., Lang, Z., Zhang, H. & ZHU, J. K. (2016), "The DNA demethylase ROS1 targets genomic regions with distinct chromatin modifications", Nat Plants, Vol. 2 No. 11, pp. 16169.
  3. Yanfei Mao, Zhengjing Zhang, Zhengyan Feng, Pengliang Wei, Hui Zhang, Jose Ramon Botella and Jian-Kang Zhu*(2015).. Development of germ-line-specific CRISPR-Cas9 systems to improve the production of heritable gene modifications in Arabidopsis. plant Biotechnology Journal,doi: 10.1111/pbi.12468.
  4. Yueh-Ju Hou, Yingfang Zhu, Pengcheng Wang, Yang Zhao, Shaojun Xie, Giorgia Batelli, Bangshing Wang, Cheng-Guo Duan, Xingang Wang, Lu Xing, Mingguang Lei, Jun Yan, Xiaohong Zhu, Jian-Kang Zhu*.(2016). Type One Protein Phosphatase 1 and Its Regulatory Protein Inhibitor 2 Negatively Regulate ABA Signaling. PLoS Genetics 12(3): e1005835. doi: 10.1371/journal.pgen.1005835.
  5. Dong-Lei Yang, Guiping Zhang, Kai Tang, Jingwen Li, Lan Yang, Huan Huang, Heng Zhang and Jian-Kang Zhu*.(2015). Dicer-independent RNA-directed DNA methylation in Arabidopsis. Cell Research doi:10.1038/cr.2015.145.
  6. Zhulong Chan*, Yanping Wang, Minjie Cao, Yuehua Gong, Zixin Mu, Haiqing Wang, Yuanlei Hu, Xin Deng, Xin-Jian He, Jian-Kang Zhu*.(2015). RDM4 modulates cold stress resistance in Arabidopsis partially through the CBF-mediated pathway. New Phycologist, doi: 10.1111/nph.13727.
  7. Xiangqiang Zhan, Bilian Qian, Fengqiu Cao, Wenwu Wu, Lan Yang, Qingmei Guan, Xianbin Gu, Pengcheng Wang, Temiloluwa A. Okusolubo, Stephanie L. Dunn, Jian-Kang Zhu & Jianhua Zhu (2015).. An Arabidopsis PWI and RRM motif-containing protein is critical for pre-mRNA splicing and ABA responses. Nature Communications,6:8139.doi:10.1038/ncomms9139.
  8. Hui Zhang, Jinshan Zhang, Pengliang Wei, Botao Zhang, Feng Gou, Zhengyan Feng, Yanfei Mao, Lan Yang, Heng Zhang, Nanfei Xu,* and Jian-Kang Zhu,*. The CRISPR/Cas9 system produces specific and homozygous targeted gene editing in rice in one generation Plant Biotechnology Journal Article first published online: 23 MAY 2014 DOI: 10.1111/pbi.12200.
  9. Chizuko Yamamuro,Daisuke Miki, Zhimin Zheng, Jun Ma, Jing Wang, Zhenbiao Yang, Juan Dong & Jian-Kang Zhu. Overproduction of stomatal lineage cells in Arabidopsis mutants defective in active DNA demethylation Nature Communications. 5, Article number: 4062 doi:10.1038/ncomms5062 Received 03 March 2014 Accepted 07 May 2014 Published 05 June 2014.
  10. Yang Zhao*, Lu Xing*, Xingang Wang, Yueh-Ju Hou, Jinghui Gao, Pengcheng Wang, Cheng-Guo Duan, Xiaohong Zhu, and Jian-Kang Zhu. The ABA Receptor PYL8 Promotes Lateral Root Growth by Enhancing MYB77-Dependent Transcription of Auxin-Responsive Genes Sci. Signal., 3 June 2014 Vol. 7, Issue 328, p. ra53 DOI: 10.1126/scisignal.2005051.
  11. Zhengyan Feng, Yanfei Mao, Nanfei Xu, Botao Zhang, Pengliang Wei, Dong-Lei Yang, Zhen Wang, Zhengjing Zhang, Rui Zheng, Lan Yang, Liang Zeng, Xiaodong Liu, Jian-Kang Zhu. Multigeneration analysis reveals the inheritance, specificity, and patterns of CRISPR/Cas-induced gene modifications in Arabidopsis. Proc Natl Acad Sci U S A. 2014 Feb 18. Doi: 10.1073/pnas.1400822111
  12. Mingguang Lei*, Honggui La*, Kun Lu, Pengcheng Wang, Daisuke Miki, Zhizhong Ren, Cheng-Guo Duan, Xingang Wang, Kai Tang, Liang Zeng, Lan Yang, Heng Zhang, Wenfeng Nie, Pan Liu, Jianping Zhou, Renyi Liu, Yingli Zhong, Dong Liu, Jian-Kang Zhu. Arabidopsis EDM2 promotes IBM1 distal polyadenylation and regulates genome DNA methylation patterns. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):527-32.
  13. Heng Zhang, Xin-Jian He, Jian-Kang Zhu*. RNA-directed DNA methylation in plants: Where to start? RNA biology. 2013 Sep 6;10(10):1593-1596.
  14. Chao-Feng Huang, Daisuke Miki, Kai Tang, Hao-Ran Zhou, Zhimin Zheng, Wei Chen, Ze-Yang Ma,Lan Yang, Heng Zhang, Renyi Liu, Xin-Jian He, Jian-Kang Zhu*. A Pre-mRNA-Splicing Factor Is Required for RNA-Directed DNA Methylation in Arabidopsis. PLoS Genet. 2013;9(9):e1003779.
  15. Yanfei Mao, Hui Zhang, Nanfei Xu, Botao Zhang, Feng Gou and Jian-kang Zhu. Application of the CRISPR-Cas system for efficient genome engineering in plants. Mol Plant. 2013 Nov;6(6):2008-11.
  16. Zhengyan Feng*, Botao Zhang*, Wona Ding, Xiaodong Liu, Dong-Lei Yang, Pengliang Wei, Fengqiu Cao, Shihua Zhu, Feng Zhang, Yanfei Mao, Jian-Kang Zhu*. Efficient genome editing in plants using a CRISPR/Cas system.
  17. Xiaojie Li, Weiqiang Qian, Yusheng Zhao, Chunlei Wang, Jie Shen, Jian-Kang Zhu* and Zhizhong Gong*. Antisilencing role of the RNA-directed DNA methylation pathway and a histone acetyltransferase in Arabidopsis. Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11425-30.
  18. Weiqiang Qian*, Daisuke Miki*, Heng Zhang, Yunhua Liu, Xi Zhang, Kai Tang, Yunchao Kan, Honggui La, Xiaojie Li, Shaofang Li, Xiaohong Zhu, Xiaobing Shi, Kangling Zhang, Olga Pontes, Xuemei Chen, Renyi Liu, Zhizhong Gong,Jian-Kang Zhu*. A histone acetyltransferase regulates active DNA demethylation in Arabidopsis. Science. 2012; 336(6087):1445-8.
  19. Xiangqiang Zhan, Bangshing Wang, Hongjiang Li, Renyi Liu, Rajwant K. Kalia, Jian-Kang Zhu and Viswanathan Chinnusamy. Arabidopsis proline-rich protein important for development and abiotic stress tolerance is involved in microRNA biogenesis. Proc Natl Acad Sci U S A. 2012; 109(44):18198-203.
  20. Xiaohong Zhu*, Ying Feng, Gaimei Liang, Na Liu, Jian-Kang Zhu*. Aequorin-based luminescence imaging reveals stimulus- and tissue-specific Ca2+ dynamics in Arabidopsis plants. Mol Plant. 2013 Mar;6(2):444-55.
  21. Heng Zhang, Ze-Yang Ma, Liang Zeng, Kaori Tanaka, Cui-Jun Zhang, Jun Ma, Ge Bai, Pengcheng Wang, Su-Wei Zhang, Zhang-Wei Liu, Tao Cai, Kai Tang, Renyi Liu, Xiaobing Shi, Xin-Jian He, and Jian-Kang Zhu. DTF1 is a core component of RNA-directed DNA methylation and may assist in the recruitment of Pol IV. Proc Natl Acad Sci U S A. 2013 May 14;110(20):8290-5.
  22. Minjie Cao, Xue Liu, Yan Zhang, Xiaoqian Xue, X Edward Zhou, Karsten Melcher, Pan Gao, Fuxing Wang, Liang Zeng, Yang Zhao, Yang Zhao, Pan Deng, Dafang Zhong, Jian-Kang Zhu, H Eric Xu and Yong Xu. An ABA-mimicking ligand that reduces water loss and promotes drought resistance in plants. Cell Res. 2013 Aug;23(8):1043-54