演讲嘉宾--仇子龙

仇子龙
仇子龙
zqiu@ion.ac.cn
http://sourcedb.sibs.cas.cn/zw/rck/201105/t20110506_3128393.html br />中国科学院上海神经科学研究所研究员、课题组长、博士生导师
研究学习经历:

1998年 上海交通大学生物学 学士;2003年 中国科学院上海生命科学研究院生物化学与分子生物学 博士;2003-2009年 加州大学San Diego分校神经生物学系 博士后;2009-至今 中科院上海生科院神经所研究员、课题组长、博士生导师。

主要集中在与自闭症及瑞特综合征等发育性神经系统疾病关系密切的基因Methyl-CpG binding protein 2 (MeCP2) 上,主要工作包括:1)发现MeCP2蛋白直接影响核内小RNA剪切加工复合物的活性而调控神经元内小RNA的产生,提出了发育性神经系统疾病致病机理的新观点(Cheng et al., Dev Cell, 2014),2) 发现MeCP2蛋白可被小泛肽化(SUMOylation)修饰而影响转录调控功能与突触发育(Cheng et la. J Neurochem, 2014),3)应用TALEN基因编辑方法得到敲除MECP2基因的食蟹猴,建立了食蟹猴基因编辑系统,为在非人灵长类中建立自闭症模型、深入研究自闭症的神经机理打下重要基础(Liu et al., Neurosci Bull, 2014)。4)应用慢病毒转基因方法得到慢病毒介导的转基因方法成功获得了8只存活的携带人类MECP2基因的转基因食蟹猴,系统性的分析了MECP2转基因食蟹猴的行为表型,发现MECP2转基因食蟹猴表现出多种自闭症患者的症状如重复刻板行为、社交障碍及升高焦虑水平等,系首次建立精神疾病的基因工程非人灵长类动物模型,为自闭症的病理与转化研究提供重要动物模型(Liu et al., Nature, 2016)。

近期发表论文:
  1. Liu, Z.#, Li, X.#, Zhang, J., Cai, Y., Cheng, T., Cheng, C., Wang, Y., Zhang, C., Nie, Yan., Chen, Z., Bian, W., Zhang, L., Xiao, J., Lu, B., Zhang, Y., Zhang., X., Sang, X., Wu, J., Xu, X., Xiong, Z., Zhang, F., Yu, X., Gong, N., Zhou, W., Sun, Q.*, Qiu, Z.* (2016) Autism-like behaviors and germline transmission in transgenic monkeys overexpressing MeCP2. Nature. 530:98-102
  2. Xin, Y., Yuan, B., Yu, B., Wang, Y., Wu, J., Zhou, W.*, Qiu, Z.* (2015) Tet1-mediated DNA demethylation regulates neuronal cell death induced by oxidative stress. Scientific Reports 5:7645. doi: 10.1038/srep07645.
    Zhang, R., Huang, M., Cao, Z., Qi, J., Qiu, Z.*, and Chiang, L.* (2015) MeCP2 plays an analgesic role in pain transmission through regulating CREB / miR-132 pathway. Molecular Pain 11: 19.
  3. Bian, W., Miao, W., He, S., Qiu, Z., Yu, X.*(2015) Coordinated Spine Pruning and Maturation Mediated by Inter-Spine Competition for Cadherin/Catenin Complexes. Cell 162(4):808-822.
  4. Liu, Z. #, Zhou, X. #, Zhu, Y. #, Chen, Z., Yu, B., Wang, Y., Zhang, C., Nie, Y., Sang, X., Cai, Y., Zhang, Y., Zhang, C., Zhou, W., Sun, Q.*, Qiu, Z.* (2014) Generation of a monkey with MECP2 mutations by TALEN-based gene targeting. Neuroscience Bulletin 30: 381-386.
  5. Cheng, T., Wang, Z., Liao, Q., Zhu, Y., Zhou, W., Xu, W., Qiu, Z.* (2014) MeCP2 suppresses nuclear microRNA processing and dendritic growth by regulating the DGCR8/Drosha complex. Developmental Cell 28:547-560
  6. Cheng, J., Huang, M., Zhu, Y., Xin, Y., Zhao, Y., Huang, J., Yu, J., Zhou, W.*, and Qiu, Z.* (2014) SUMOylation of MeCP2 is essential for transcriptional repression and hippocampal synapse development. Journal of Neurochemistry 128:798-806
  7. Zhang, Y., Mao, R., Chen, Z., Tian, M., Tong, D., Gao, Z., Li, X., Huang, M., Xu, X., Zhou, W., Li, C., Wang, J., Xu, L.*, Qiu, Z.*, (2014) Deep-brain magnetic stimulation promotes adult hippocampal neurogenesis and alleviates stress-related behaviors in mouse models for neuropsychiatric disorders. Molecular Brain 7:11 

  8. He LJ, Liu N, Cheng TL, Chen XJ, Li YD, Shu YS, Qiu ZL, Zhang XH*. (2014) Conditional deletion of Mecp2 in parvalbumin-expressing GABAergic cells results in the absence of critical period plasticity. Nature Communications 5:5036. doi: 10.1038/ncomms6036.
  9. Liu, X., Somel, M., Tang, L., Yan, Z., Jiang, X., Guo,S., Yuan,Y., Oleksiak, A., Zhang, Y., Li, N.,  Hu, Y., Chen, W., Qiu, Z.*, Pääbo, S.*, Khaitovich, P.* (2012) Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques. Genome Research 22:611-622
  10. Qiu, Z.#, Sylwestrak, E. #, Lieberman, D., Zhang, Y., Liu, X., Ghosh A.* (2012) The Rett syndrome protein MeCP2 regulates synaptic scaling. Journal of Neuroscience 32:989-994
  11. Xu, X.*, Xu, Q., Zhang, Y., Zhang, X., Cheng, T., Wu, B., Ding, Y., Lu, P., Zheng, J., Zhang, M., Qiu, Z., and Yu, X.* (2012) A case report of Chinese brothers with inherited MECP2-containing duplication: autism and intellectual disability, but not seizures or respiratory infections. BMC Medical Genetics 13: 75
会议报告摘要:
Ultra-deep sequencing reveals low-abundance mutations in ctDNA and improves early diagnosis of pancreatic cancer (4月23日,13:50 - 14:15 pm)

Pancreatic ductal adenocarcinoma (PDAC) is one of the leading cause of cancer-related death in western countries and is predicted to be the second cause of cancer-related deaths in 2020. Surgery is the only potential curative treatment of pancreatic cancer, however early diagnosis of PDAC is still a challenge. Serologic markers such as CA19-9 and CEA are now widely used in clinical practice; however, none is enough efficient in diagnosis of pancreatic cancer. Circulating tumor DNA is one of the most promising tumor marker. Here, we generated an ultra-deep sequencing method to detect 61 key oncogene and tumor suppressor gene in plasma. We tested plasma samples of 119 PDAC patients and 35 healthy donors recruited at Zhongshan Hospital Fudan University. Our results show that ultra-deep sequencing is highly efficient and robust to detect ctDNA in human plasma. Detection of driver mutilations (KRAS, TP53, and SMAD4) improve the diagnosis of pancreatic cancer, especially in early stage Lewis- patients. Out work highlights that pancreatic cancer may preserve polyclonal cancer cell containing low-abundance mutations.

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第四届肿瘤基础和转化医学前沿国际研讨会