演讲嘉宾--关新元

关新元
xyguan@hku.hk
http://www.oncology.hku.hk/staff_xyguan.html
香港大学癌症研究中心主任,肝病研究国家重点实验室副主任。 国家特聘专家
研究学习经历:

于1993年获得美国亚利桑那大学遗传学博士,于1993年9月加入美国NIH人类基因组研究所任Senior Staff Fellow及染色体显微切割研究组组长。1999年加入香港大学,任香港大学临床肿瘤系副教授、肿瘤遗传实验室主任,2007年晋升为教授,2016年获得香港大学明德教授席(陈一微基金教授席-癌病研究学)。目前任香港大学癌症研究中心主任,肝病研究国家重点实验室副主任。2007年被中山大学聘为特聘教授。现主要从事人类恶性肿瘤的分子遗传学研究20余年,曾在国际上首创显微-荧光原位杂交技术,应用染色体显微切割技术并结合杂交筛选技术,鉴定了多个染色体区带扩增区内的癌基因,包括AIB1、EIF5A2和CHD1L等。也曾是国际上首先报道CD133是肝癌肿瘤干细胞的表面分子标记物的实验室之一。目前主要研究与肝癌和食道癌发生发展相关的基因、肿瘤干细胞和肿瘤微环境等。已在SCI收录的杂志上发表学术论文280余篇,被引用超过19000次(Google Scholar)。1998年获得杰出青年科学基金(B类),2010年获得国家自然科学奖二等奖(第4完成人),2012年获得国家科技进步奖一等奖(第2完成人),2012年获得香港大学杰出科学研究奖。

近期发表论文:
  1. Liu M, Chen L, Ma NF, Chow RK, Li Y, Song Y, Chan TH, Fang S, Yang X, Xi S, Jiang L, Li Y, Zeng TT, Li Y, Yuan YF, Guan XY*. CHD1L promotes lineage reversion of hepatocellular carcinoma through opening chromatin for key developmental transcription factors. Hepatology 2016;63:1544-59.
  2. Song Y, Pan G, Chen L, Ma S, Zeng T, Chan TH, Li L, Lian Q, Chow R, Cai X, Li Y, Li Y, Liu M, Li Y, Zhu Y, Wong N, Yuan YF, Pei D, Guan XY*. Down-regulation of tumor suppressor ATOH8 increases cancer stemness in hepatocellular carcinoma. Gastroenterology 2015;149:1068-81.
  3. Li Y*, Fu L, Qin Y, Zeng T, Zhou J, Zeng ZL, Chen J, Cao TT, Ban X, Qian C, Cai Z, Xie D, Huang P, Guan XY*. Increased expression of EIF5A2, via hypoxia or gene amplification, contributes to metastasis and angiogenesis of esophageal squamous cell carcinoma. Gastroenterology 2014;146:1701-13.
  4. Liu M, Li Y, Chen L, Chan TH, Song Y, Fu L, Zeng TT, Dai YD, Zhu YH, Li Y, Chen J, Yuan YF, Guan XY*. Allele-specific imbalance of oxidative stress-induced growth inhibitor 1 associates with progression of hepatocellular carcinoma. Gastroenterology 2014;146:1084-96.
  5. Chen L, Li Y, Lin CH, Chan TH, Chow RK, Song Y, Liu M, Yuan YF, Fu L, Kong KL, Qi L, Li Y, Zhang N, Tong AH, Kwong DL, Man K, Lo CM, Lok S, Tenen DG*, Guan XY*. Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma. Nature Medicine 2013;19(2):209-16.
  6. Li Y, Chen L, Chan TH, Liu M, Kong KL, Qiu JL, Yuan YF, Guan XY*. SPOCK1 is regulated by CHD1L and blocks apoptosis and promotes HCC cell invasiveness and metastasis in mice. Gastroenterology 2013;144:179-91.
  7. Kong KL, Kwong DL, Chan TH, Law SY, Chen L, Li Y, Qin YR, Guan XY*. MicroRNA-375 inhibits tumour growth and metastasis in oesophageal squamous cell carcinoma through repressing insulin-like growth factor 1 receptor. Gut 2012;61:33-42.
  8. Fu L, Zhang C, Zhang LY, Dong SS, Lu LH, Chen J, Dai Y, Li Y, Kong KL, Kwong DL Guan XY*. Wnt2 secreted by tumour fibroblasts promotes tumour progression in oesophageal cancer by activation of the Wnt/β-catenin signalling pathway. Gut 2011;60:1635-43.
  9. Ma S*, Tang KH, Chan YP, Lee TK, Kwan PS, Castilho A, Ng I, Man K, Wong N, To KF, Zheng BJ, Lai PB, Lo CM, Chan KW*, Guan XY*. miR-130b promotes CD133(+) liver tumor-initiating cell growth and self-renewal via tumor protein 53-induced nuclear protein 1. Cell Stem Cell 2010;7:694-707.
  10. Chen L, Chan TH, Yuan YF, Hu L, Huang J, Ma S, Wang J, Dong SS, Tang KH, Xie D, Li Y, Guan XY*. CHD1L promotes hepatocellular carcinoma progression and metastasis in mice and is associated with these processes in human patients. Journal of Clinical Investigation 2010;120:1178-91.
会议报告摘要:
Integrin α7 is a functional cancer stem cell surface marker in esophageal squamous cell carcinoma(4月22日,16:20-16:50pm)

Non-CG methylation has been associated with stemness regulation in embryonic stem cells. By comparing differentially expressed genes affected by non-CG methylation between tumor and corresponding non-tumor tissues in esophageal squamous cell carcinoma (ESCC), Integrin α7 (ITGA7) was characterized as a novel cancer stem cell (CSC) marker. Clinical data showed that a high-frequency of ITGA7+ cells in ESCC tissues was significantly associated with poor differentiation (P=0.001), lymph node metastasis (P=0.005) and worse prognosis (P<0.001). Functional studies demonstrated that both sorted ITGA7+ cells and ITGA7 overexpressing cells displayed enhanced stemness features, including elevated expression of stemness-associated genes and epithelial-mesenchymal transition features, as well as increased abilities to self-renew, differentiate and resist chemotherapy. Mechanism studies found that ITGA7 regulates CSC properties through the activation of the FAK mediated signaling pathways. As knockdown of ITGA7 can effectively reduce the stemness of ESCC cells, ITGA7could be a potential therapeutic target in ESCC treatment.

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第四届肿瘤基础和转化医学前沿国际研讨会