演讲嘉宾--黎孟枫

研究学习经历:

主要学术兴趣在于认识炎症过程、肿瘤发生、病原感染三者之间的分子联系,研究与此相关的信号控制机理及其临床意义,特别是其中NF-kappaB信号通路所涉及的新调控分子与工作机制;研究NF-κB调控分子在肿瘤发生发展和病原重症感染两大类疾病中的临床意义,例如可用于诊断、预后判断的新分子标志物和治疗新靶点。研究中所涉及疾病模型包括脑胶质瘤、肺癌、乳腺癌、重症登革、重症肝炎、重症呼吸道病毒病等。现任国务院学位委员会学科评议组成员,教育部临床医学专业认证专家委员会成员,《The Journal of Gene Medicine》主编,中国微生物学会《病毒学报》副总编辑等学术兼职。

近期发表论文:
  1. Xun Zhu, Zhenjian He, Yiwen Hu, Weitao Wen, Cuiji Lin, Jianchen Yu, Jing Pan, Ran Li, Haijing Deng, Shaowei Liao, Jie Yuan, Jueheng Wu, Jun Li, Mengfeng Li*. MicroRNA-30e* suppresses dengue virus replication by promoting NF-κB–dependent IFN production. PLoS Neglected Tropical Diseases. 8(8):e3088 (published online, totally 8 pages), 2014.
  2. Xun Zhu, Zhenjian He, Jie Yuan, Weitao Wen, Xuan Huang, Yiwen Hu, Cuiji Lin, Jing Pan, Ran Li, Haijing Deng, Shaowei Liao, Rui Zhou, Jueheng Wu, Jun Li, Mengfeng Li*. IFITM3-containing exosome as a novel mediator for anti-viral response in dengue virus infection. Cellular Microbiology. In press, 2014.
  3. Junchao Cai, Hongyu Guan, Lishan Fang, Yi Yang, Xun Zhu, Jie Yuan, Jueheng Wu and Mengfeng Li *. MicroRNA-374a activates Wnt/β-catenin signaling to promote breast cancer metastasis. The Journal of Clinical Investigation.123(2):566-579. 2013
  4. Zhe Ying, Yun Li, Jueheng Wu, Xun Zhu, Yi Yang, Han Tian, Wei Li, Bo Hu, Shi-Yuan Cheng, Mengfeng Li*. Loss of miR-204 Expression Enhances Glioma Migration and Stem Cell-Like Phenotype. Cancer Research. 73(2): 990-999. 2013.
  5. Junchao Cai, Jueheng Wu, Huizhong Zhang, Lishan Fang, Yongbo Huang, Yi Yang, Xun Zhu, Rong Li, Mengfeng Li*. MiR-186 Downregulation Correlates with Poor Survival in Lung Adenocarcinoma, Where It Interferes with Cell-Cycle Regulation. Cancer Research. 73(2):756-766. 2013
  6. Junchao Cai, Lishan Fang, Yongbo Huang, Rong Li, Jie Yuan, Yi Yang, Xun Zhu, Baixue Chen, Jueheng Wu, Mengfeng Li*. MiR-205 targets PTEN and PHLPP2 to augment AKT signaling and drive malignant phenotypes in non-small cell lung cancer. Cancer Research. 73(17):5402-5415. 2013.
  7. Lili Jiang, Chuyong Lin, Libing Song, Jueheng Wu, Baixue Chen, Zhe Ying, Lishan Fang, Xiao Yan, Mian He, Jun Li*, Mengfeng Li*. MicroRNA-30e* promotes human glioma cell invasiveness in an orthotopic xenotransplantation model by disrupting the NF-κB/IκBα negative feedback loop. The Journal of Clinical Investigation. 122(1):33-47. 2012
  8. Hongyu Guan, Heng Zhang, Jueheng Wu, Jie Yuan, Zhengsong Huang* and Mengfeng Li*. IKBKE is overexpressed in glioma and contributes to resistance of glioma cells to apoptosis via activating NF-κB. Journal of Pathology. 223: 436–445. 2011
会议报告摘要:
miRNA-targeting strategies to simultaneously antagonize chemoresistance and metastasis in lung cancer (4月23日,09:20 - 09:45 am)

While cancer chemoresistance and metastasis are cliniclaly tightly linked, whether they share common molecular mechanisms and thus can be targeted with one common strategy as therapeutic intervention remains unclear. Here, we report that microRNA-128 (miR-128) is key to simultaneous development of chemoresistance and metastasis in residual non-small cell lung cancer (NSCLC) cells that have survived repeated chemotherapy. High miR-128 expression levels in NSCLC patients receiving platinum-based therapy correlates with a lack of responsiveness to chemotherapy, metastasis and poor prognosis of the disease. Mechanistically, miR-128 overactivates Wnt/β-catenin and TGF-β signaling through downregulating multiple inhibitors of the pathways. Importantly, systemic antagonism of miR-128 in animal models abrogated tumorigenesis, metastasis and chemoresistance of NSCLC. Notably, clinical studies showed correlations among miR-128 levels, activated β-catenin and TGF-β signaling, and expression of pro-EMT/pro-metastatic proteins. Our findings suggest that miR-128 targeted approaches might represent a novel strategy to simultaneously abrogate metastasis and chemoresistance in NSCLC.

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第四届肿瘤基础和转化医学前沿国际研讨会