演讲嘉宾--黄蓬

黎孟枫
黎孟枫
limf@mail.sysu.edu.cn
“长江学者”特聘教授、中山大学副校长、中山大学医学院院长、中山大学中山医学院
研究学习经历:

主要学术兴趣在于认识炎症过程、肿瘤发生、病原感染三者之间的分子联系,研究与此相关的信号控制机理及其临床意义,特别是其中NF-kappaB信号通路所涉及的新调控分子与工作机制;研究NF-κB调控分子在肿瘤发生发展和病原重症感染两大类疾病中的临床意义,例如可用于诊断、预后判断的新分子标志物和治疗新靶点。研究中所涉及疾病模型包括脑胶质瘤、肺癌、乳腺癌、重症登革、重症肝炎、重症呼吸道病毒病等。现任国务院学位委员会学科评议组成员,教育部临床医学专业认证专家委员会成员,《The Journal of Gene Medicine》主编,中国微生物学会《病毒学报》副总编辑等学术兼职。

近期发表论文:
  1. Xun Zhu, Zhenjian He, Yiwen Hu, Weitao Wen, Cuiji Lin, Jianchen Yu, Jing Pan, Ran Li, Haijing Deng, Shaowei Liao, Jie Yuan, Jueheng Wu, Jun Li, Mengfeng Li*. MicroRNA-30e* suppresses dengue virus replication by promoting NF-κB–dependent IFN production. PLoS Neglected Tropical Diseases. 8(8):e3088 (published online, totally 8 pages), 2014.
  2. Xun Zhu, Zhenjian He, Jie Yuan, Weitao Wen, Xuan Huang, Yiwen Hu, Cuiji Lin, Jing Pan, Ran Li, Haijing Deng, Shaowei Liao, Rui Zhou, Jueheng Wu, Jun Li, Mengfeng Li*. IFITM3-containing exosome as a novel mediator for anti-viral response in dengue virus infection. Cellular Microbiology. In press, 2014.
  3. Junchao Cai, Hongyu Guan, Lishan Fang, Yi Yang, Xun Zhu, Jie Yuan, Jueheng Wu and Mengfeng Li *. MicroRNA-374a activates Wnt/β-catenin signaling to promote breast cancer metastasis. The Journal of Clinical Investigation.123(2):566-579. 2013
  4. Zhe Ying, Yun Li, Jueheng Wu, Xun Zhu, Yi Yang, Han Tian, Wei Li, Bo Hu, Shi-Yuan Cheng, Mengfeng Li*. Loss of miR-204 Expression Enhances Glioma Migration and Stem Cell-Like Phenotype. Cancer Research. 73(2): 990-999. 2013.
  5. Junchao Cai, Jueheng Wu, Huizhong Zhang, Lishan Fang, Yongbo Huang, Yi Yang, Xun Zhu, Rong Li, Mengfeng Li*. MiR-186 Downregulation Correlates with Poor Survival in Lung Adenocarcinoma, Where It Interferes with Cell-Cycle Regulation. Cancer Research. 73(2):756-766. 2013
  6. Junchao Cai, Lishan Fang, Yongbo Huang, Rong Li, Jie Yuan, Yi Yang, Xun Zhu, Baixue Chen, Jueheng Wu, Mengfeng Li*. MiR-205 targets PTEN and PHLPP2 to augment AKT signaling and drive malignant phenotypes in non-small cell lung cancer. Cancer Research. 73(17):5402-5415. 2013.
  7. Lili Jiang, Chuyong Lin, Libing Song, Jueheng Wu, Baixue Chen, Zhe Ying, Lishan Fang, Xiao Yan, Mian He, Jun Li*, Mengfeng Li*. MicroRNA-30e* promotes human glioma cell invasiveness in an orthotopic xenotransplantation model by disrupting the NF-κB/IκBα negative feedback loop. The Journal of Clinical Investigation. 122(1):33-47. 2012
  8. Hongyu Guan, Heng Zhang, Jueheng Wu, Jie Yuan, Zhengsong Huang* and Mengfeng Li*. IKBKE is overexpressed in glioma and contributes to resistance of glioma cells to apoptosis via activating NF-κB. Journal of Pathology. 223: 436–445. 2011
会议报告摘要:
Mechanisms switching TGF-β functions to its pro-metastatic signaling arm in lung cancer (4月22日,15:15 - 15:40 pm)

It has been well recognized that In many cancer types, TGF-β can be functioning both as a tumor suppressor, which usually occurs during early tumor development, and as a promoter of tumor metastasis in the advanced stages of cancer. Identifying molecular mechanisms that act to rewire TGF-β signaling toward its pro-metastatic role in cancer cells will facilitate development of novel targeting strategies antagonizing the pro-metastatic function of TGF-β without attenuating the its tumor-suppressive effects. Our current study using non–small-cell lung carcinoma (NSCLC) cell lines, animal models, and clinical specimens demonstrates that suppression of SMAD2, with SMAD3 function intact, switches TGF-β–induced transcriptional responses to a pro-metastatic state. Importantly, we identified chaperonin containing TCP1 subunit 6A (CCT6A) as an inhibitor and direct binding protein of SMAD2 and found that CCT6A suppresses SMAD2 function in NSCLC cells and promotes metastasis. Selective inhibition of SMAD3 or CCT6A efficiently suppresses TGF-β–mediated metastasis. Our findings provide a mechanism that directs TGF-β signaling toward its prometastatic arm and may contribute to the development of therapeutic strategies targeting TGF-β for NSCLC.

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第四届肿瘤基础和转化医学前沿国际研讨会