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企业嘉宾--伍建

伍建
伍建
Email: jw2231@mygeno.cn
北京迈基诺基因科技股份有限公司首席科学家; 2016年入选第二批国家“万人计划”科技创业领军人才;曾任美国霍普金斯大学Sidney Kimmel癌症研究中心助理教授(2011)。 验室主任
研究学习经历:

2004年于北京大学获得学士学位,其后在美国University of Columbia University获得博士研究生学位(2004-2008);在University of Columbia University接受博士后训练 (2008-2011),在美国霍普金斯大学Sidney Kimmel癌症研究中心担任兼职助理教授(2011);2011年回国创办北京迈基诺基因科技股份有限公司。

伍建长期致力于将基因捕获专利技术应用于临床检测,先后开发出近百种捕获测序试 剂,目前已广泛应用于临床辅助诊断。2011年-2016年,伍建博士先后被评为“北京市海聚人才”, “北京市特聘专家”;获得“北京市科技新星”,“北京市拔尖人才”,“国家科技部创新创业人才”等称号;2016年入选第二批国家“万人计划”科技创业领军人才。

首席科学家伍建博士发表的文章:
  1. Kinde I, Bettegowda C, Wang Y, Wu J, Agrawal N, Shih IeM, Kurman R, Dao F, Levine DA, Giuntoli R, Roden R, Eshleman JR, Carvalho JP, Marie SK, Papadopoulos N, Kinzler KW, Vogelstein B, Diaz LA Jr. Evaluation of DNA from the papanicolaou test to detect ovarian and endometrial cancers. Sci Transl Med. 2013 Jan 9;5(167):167
  2. Mark Sausen, Rebecca J. Leary, Siân Jones,  Jian Wu, C. Patrick Reynolds, Xueyuan Liu, Amanda Blackford, Giovanni Parmigiani, Luis A. Diaz, Jr.1, Nickolas Papadopoulos, Bert Vogelstein, Kenneth W. Kinzler, Victor E. Velculescu, Michael D. Hogarty. Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma. Nat Genet. 2012 Dec 16;45(1):12-7.
  3. Hanno Matthaei1,4,†, Jian Wu5,6,†, Marco Dal Molin1, Marija Debeljak1, Philipp Lingohr4, Nora Katabi7, David S. Klimstra7, N. Volkan Adsay8, James R. Eshleman1,2, Richard D. Schulick1,3, Kenneth W. Kinzler5, Bert Vogelstein5,9, Ralph H. Hruban1,2, Anirban Maitra1,2,*GNAS codon 201 mutations are uncommon in intraductal papillary neoplasms of the bile duct. HPB. 18 JUN 2012. (Co-first author).
  4. Luis A. Diaz Jr, Richard Williams, JianWu, Isaac Kinde, J. Randolph Hecht, Jordan Berlin, Benjamin Allen, Ivana Bozic, Johannes G. Reiter, Martin A. Nowak, Kenneth W. Kinzler, Kelly S. Oliner, Bert Vogelstein. The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers. Nature, June 28th, 2012
  5.  Mitsuro Kanda*, Hanno Matthei*, Jian Wu*, Seung-Mo Hong, Jun Yu, Michael Borges,   Ralph H. Hruban, Anirban Maitra, Bert Vogelstein, Michael Goggins. A genetic basis for  the initiation of pancreatic intraepithelial neoplasias. Gastroenterology 2012, Jan 5th.  (Co-first author).
  6. Jian Wu, Yuchen Jiao, Marco Dal Molin, Anirban Maitra, Roeland DeWilde, Laura Wood, James Eshleman, Michael Goggins, Marcia L. Canto, Richard D. Schulick, Barish H. Edil, Christopher L. Wolfgang, Michael Choti, Volkan Adsay, David Klimstra, G. Johan A. Offerhaus, Alison P. Klein, Levy Kopelovich, Rachel Karchin, Peter J. Allen, C. Max Schmidt, Luis A. Diaz, Jr., Kenneth W Kinzler, Nickolas Papadopoulos, Ralph H. Hruban, Bert Vogelstein. Whole exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways. Proc Natl Acad Sci USA. 2011: 108 (52) 21188-21193.
  7. Wu J, Matthaei H, Maitra A, Dal Molin M, Wood LD, Eshleman JR, Goggins M, Canto MI, Schulick RD, Edil BH, Wolfgang CL, Klein AP, Diaz LA Jr, Allen PJ, Schmidt CM, Kinzler KW, Papadopoulos N, Hruban RH, Vogelstein B. Recurrent GNAS Mutations Define an Unexpected Pathway for Pancreatic Cyst Development. Science Translational Medicine. 2011 Jul 20; 3(92):92ra66.
  8. Bert Vogelstein, Kinzler KW, Papadopoulos N, Jian Wu. ‘Capturing specific sequences using modified oligonucleotide probes’ US Provisional Patent in process 2011.
  9. Bert Vogelstein, Kinzler KW, Papadopoulos N, Jian Wu, Luis Diaz, Hanno Matthei, Ralph Hruban, Anirban Maitra ‘Identification of GNAS mutations in pancreatic cystic lesions’ US Provisional Patent in process 2011.
  10. Kinde I, Wu J, Papadopoulos N, Kinzler KW, Vogelstein B. Detection and quantification of rare mutations with massively parallel sequencing. Proc Natl Acad Sci USA. 2011 Jun 7;108 (23):9530-5.
  11. He J*, Wu J*, Jiao Y, Wagner-Johnston N, Ambinder RF, Diaz LA Jr, Kinzler KW, Vogelstein B, Vogelstein B. “IgH gene rearrangements as plasma biomarkers in Non-Hodgkin's Lymphoma patients”. Oncotarget, Vol 2, No 3, 178-185, 2011. (Co-first author)
  12.  Wang Q, Chaerkady R, Wu J, Hwang HJ, Papadopoulos N, Kopelovich L, Maitra A, Matthaei H, Eshleman JR, Hruban RH, Kinzler KW, Pandey A, Vogelstein B. “Mutant proteins as cancer-specific biomarkers”. Proceedings of the National Academy of Sciences of the United States of America, 108, (6) 2444-2449, 2011.
  13.  He Y, Wu J, Dressman DC, Iacobuzio-Donahue C, Markowitz SD, Velculescu VE, Diaz LA Jr, Kinzler KW, Vogelstein B, Papadopoulos N. “Heteroplasmic mitochondrial DNA mutations in normal and tumor cells”. Nature, 464, 610–614, 2010.
  14. Guo J, Xu N, Li Z, Zhang S, Wu J, Kim DH, Sano Marma M, Meng Q, Cao H, Li X, Shi S, Yu L, Kalachikov S, Russo JJ, Turro NJ, Ju J. “Four-color DNA Sequencing with 3’-O-modified Nucleotide Reversible Terminators and Cleavable Fluorophore-modified Dideoxynucleotides”. Proceedings of the National Academy of Sciences of the United States of America. (2008) 105: 9145-9150.
  15. Jingyue Ju, Wu, Jian. Methods for Pyrosequencing of Nucleic Acids Using 3'-Omodified Deoxynucleoside Triphosphates. PCT Int. Appl. (2007), WO 2007002204 A2.
  16. Jingyue Ju, Jian Wu, Zengmin Li. DNA sequencing by synthesis using raman and infrared spectroscopy detection. US Provisional Applicaiton No.61/489191, 2011
  17. Wu, Jian; Zhang, Shenglong; Meng, Qinglin; Cao, Huanyan; Li, Zengmin; Li, Xiaoxu; Shi, Shundi; Kim, Dae Hyun; Bi, Lanrong; Turro, Nicholas J; Ju, Jingyue. “3’-O-modified Nucleotides as Reversible Terminators for Pyrosequencing”. Proceedings of the National Academy of Sciences of the United States of America2007, 104, 16462-16467.
  18. Ju J, Kim DH, Bi L, Meng Q, Bai X, Li Z, Li X, Marma MS, Shi S, Wu J, Edwards JR, Romu A, Turro NJ. “Four-color DNA Sequencing by Synthesis Using Cleavable Fluorescent Nucleotide Reversible Terminators”. Proceedings of the National Academy of Sciences of the United States of America2006, 103, 19635-19640.
会议报告摘要:
捕获测序在肿瘤研究中的应用 (4月21日,14:40-15:08 pm)

相对于全外显子测序以及全基因组测序,目标区域捕获测序在肿瘤研究中的价值越来越大。捕获测序不仅能够帮助科研工作者灵活的进行科研设计,而且其更重要的意义是在于利于临床转化。

除了常规的DNA捕获测序,迈基诺陆续开发出了多种捕获测序技术平台,包括甲基化捕获测序,病原微生物捕获测序以及LncRNA捕获测序,适用于科研工作者从更多纬度进行科学研究。 通过对启动子区域设计甲基化捕获探针,可以深入了解肿瘤相关基因甲基化水平变化的规律;病原微生物捕获测序技术可以实现对感染性肿瘤的发病机制有更好的研究办法,比如病毒的整合分析;对lncRNA捕获测序则可以解决目前低表达lncRNA分析的难题,可以更加准确的找到和肿瘤相关的lncRNA。

联手迈基诺共同研究目标区域捕获测序,为您的科研工作带来突破进展!

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第四届肿瘤基础和转化医学前沿国际研讨会