企业嘉宾(根据作报告的序列安排)

企业嘉宾--许明炎

易鑫
中国科学院北京基因组研究所博士研究生,基因 组学遗传学专业
研究学习经历:

易鑫,男,1984年10月生,中国科学院北京基因组研究所博士研究生,基因组学遗传学专业。现任北京吉因加科技有限公司董事长兼首席技术官,从事基因组医学、转化医学领域的科学研究和技术研发工作,目前主要从事肿瘤基因检测工作,探索高通量测序技术在肿瘤精准医学中的应用。近年先后主持完成研究项目(课题)6项。获得荣誉奖项2项。专利8项。相关研究成果已陆续在Science、Nature、NG、IJC、AJCP、Plos ONE等杂志上发表,截止到目前已发表SCI文章24篇,累计影响因子超过199。

近期发表论文:
  1. Xin Yi, Yu Liang,.. Jian Wang, et al. Sequencing of 50 human exomes reveals adaptation to high altitude. Science. 2010 Jul 2;329(5987):75-8. doi: 10.1126/ science.1190371.
  2. Jun Wang,.. Xin Yi,.. Jian Wang, et al. The diploid genome sequence of an Asian individual. Nature. 456, 60-65 (6 November 2008) | doi:10.1038/nature07484.
  3. Emilia Huerta-Sánchez,.. Xin Yi,..Rasmus Nielsen, et al. Altitude adaptation in Tibetans caused by introgression of Denisovan-like DNA. Nature. 2 July 2014; doi:10.1038/nature13408.
  4. Pei-Wen Chiang,.. Xin Yi,.. Ming Qi, et al. Exome sequencing identifies NMNAT1 mutations as a cause of Leber congenital amaurosis. Nature Genetics. 2012 Sep;44(9):972-4. doi: 10.1038/ng.2370.
  5. Jerome L. Belinson1,.. Xin Yi and Philip E. Castle, et al. Improved sensitivity of vaginal self-collection and high-risk human papillomavirus testing.
  6. Xiaoming Wei,..Liying Cui* and Xin Yi*. Targeted next-generation sequencing as a comprehensive test for patients with and female carriers of DMDBMD a multi-population diagnostic study. Eur J Hum Genet. 2014 Jan;22(1):110-8. doi: 10.1038/ejhg.2013.82.
  7. JeromeL. Belinson,.. Xin Yi and RuifangWu. The development and evaluation of a community based model for cervical cancer screening based on self-sampling. Gynecol Oncol. 2014 Mar;132(3):636-42. doi: 10.1016/ j.ygyno. 2014.01.006.
  8. Xiaoming We*i, Xiangchun Ju*, Xin Yi*,..Jian Huang, et al. Identification ofSequence Variants in Genetic Disease-Causing Genes Using Targeted Next-Generation Sequencing. PLoS One. 2011;6(12): e29500. doi: 10.1371/journal.pone.0029500.
  9. Fang Chen,.. Xin Yi,.. Jian Wang, et al. Transcriptome and Network Changes in Climbers at Extreme Altitudes. PLoS One. 2012;7(2):e31645. doi: 10.1371/ journal.pone.0031645.
  10. Shanshan Yu,.. Xin Yi* and Jiansheng Xie*. Identification of Two Missense<Mutations of ERCC6 in Three Chinese Sisters with Cockayne Syndrome by Whole Exome Sequencing. PLoS One. 2014 Dec 2;9(12):e113914. doi: 10.1371/ journal.pone.0113914.
  11. Xiaoming Wei,.. Xiangchun Ju and Xin Yi*. A novel mutation of IDS gene in a Chinese patient with mucopolysaccharidosis II by next-generation sequencing. Clin Chim Acta. 2011 Nov 20;412(23-24):2340-2. doi: 10.1016/ j.cca.2011.08.031.
  12. Yan Sun,.. Wei Wang and Xin Yi*. Analysis of a Chinese pedigree with Zellweger syndrome reveals a novel PEX1 mutation by next-generation sequencing. Clin Chim Acta. 2013 Feb 18;417:57-61. doi: 10.1016/ j.cca. 2012.12.005.
  13. Xiaoming We,.. Wei Wang and Xin Yi*. Next-generation sequencing identifies a novel compound heterozygous mutation in MYO7A in a Chinese patient with Usher Syndrome 1B. Clin Chim Acta. 2012 Nov 20;413(23-24):1866-71. doi: 10.1016/j.cca.2012.07.022.
  14. Hui Du,.. Xin Yi and Jerome L. Belinson. A New PCR-Based Mass Spectrometry System for High-Risk HPV, Part II Clinical Trial. Am J Clin Pathol. 2011 Dec;136(6):920-3. doi: 10.1309.
  15. Xin Yi, Jingjing Li,.. Jian Wang, et al. A New PCR-Based Mass Spectrometry System for High-Risk HPV, Part I Methods. Am J Clin Pathol. 2011 Dec; 136(6):913-9. doi: 10.1309.
  16. Xin Yi, Jing Zou,.. Jerome L. Belinson, et al. Development and Validation of a New HPV Genotyping Assay Based on Next Generation Sequencing . Am J Clin Pathol. 2014 Jun;141(6):796-804. doi: 10.1309.
  17. Rui Gao,.. Xin Yi*, Jun Wang* and Torben Hansen*. Evaluation of a target region capture sequencing platform using monogenic diabetes as a study-model . BMC Genet. 2014 Jan 29;15:13. doi: 10.1186/1471-2156-15-13.
  18. Shuqi Xie,.. Ling Yang and Xin Yi*. Detection of truncated dystrophin lacking the C-terminal domain in a Chinese pedigree by next-generation sequencing. Gene. 2012 May 10;499(1):139-42. doi: 10.1016/j.gene.2012.03.029.
  19. J. Li,.., L. Wang and X. Yi*. Characterization of 236 novel alleles at the HLA-A, -B, -C, -DRB1, -DQB1 and -DPB1 loci from China Marrow Donor Program. Tissue Antigens. 2011 Oct;78(4):267-70. doi: 10.1111/ j.1399-0039.2011.01731.x.
  20. Shanfei Ge,.., Xin Yi and Fei Liu. Deep sequencing analysis of microRNA expression in porcine serum-induced hepatic fibrosis rats. Ann Hepatol. 2014 Jul-Aug;13(4):439-49.
  21. Yanfang Guan,.., Dongxian Zhou and Xin Yi*. Detection of inherited mutations for hereditary cancer using target enrichment and next generation sequencing. Fam Cancer. 2014 Aug 24. DOI 10.1007/s10689-014-9749-9
  22. Yingxin Hana,.., Ling Yanga and Xin Yi*. Analysis of hepatitis B virus genotyping and drug resistance gene mutations based on massively parallel sequencing. J Virol Methods. 2013 Nov;193(2):341-7. doi: 10.1016/ j.jviromet. 2013.06.015.
  23. Junqing Zhang,.. Xin Yi,.. Qiuju Wange, et al. Newborn hearing concurrent genetic screening for hearing impairment -A clinical practice in 58,397 neonates in Tianjin, China. Int J Pediatr Otorhinolaryngol. 2013 Dec;77(12): 1929-35. doi: 10.1016/j.ijporl.2013.08.038.
  24. Gang Liu,.. Yi Yang and Xin Yi*. A novel mutation of the SCL25A13 gene in a Chinese patient with citrin 2 deficiency detected by target next-generation sequencing. Gene. 2014 Jan 10;533(2):547-53. doi: 10.1016/j.gene.2013.10.021.
会议报告摘要:
肿瘤基因大数据与精准医疗 (4月21日,15:08-15:36 pm)

以“肿瘤基因大数据-基线数据库”为主线,以“自己跟自己比,自己跟别人比”的核心理念开展12条cfDNA基线计划,建立中国人肿瘤基线数据库,技术基线辨真假,生物学基线辨是否,临床基线验获益。基线数据库的建立并结合mTBI指数、mClone算法进行有效挖掘,搭建起基因信息到临床决策的桥梁,力求为临床肿瘤医生提供精准参考依据,帮助肿瘤患者走对临床决策每一步。

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第四届肿瘤基础和转化医学前沿国际研讨会